Article
Advanced glycation end-products (AGEs) induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal-regulated kinases (ERK).
Molecular and cellular biochemistry - 1 Aug 2003
Cortizo Ana M, Lettieri María G, Barrio Daniel A, Mercer Natalia, Etcheverry Susana B, McCarthy Antonio D
Abstract excerpt
An increase in the interaction between advanced glycation end-products (AGEs) and their receptor RAGE is believed to contribute to the pathogenesis of chronic complications of Diabetes mellitus, which can include bone alterations such as osteopenia. We have recently found that extracellular AGEs...
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