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Article

Folding of fumarase during mitochondrial import determines its dual targeting in yeast.

The Journal of biological chemistry - 14 Nov 2003

Sass Ehud, Karniely Sharon, Pines Ophry

Abstract excerpt

We have previously proposed that a single translation product of the FUM1 gene encoding fumarase is distributed between the cytosol and mitochondria of Saccharomyces cerevisiae and that all fumarase translation products are targeted and processed in mitochondria before distribution. Thus, fumarase processed in mitochondria returns to the cytosol. In the current work, we (i) generated mutations throughout the...

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PMID: 12960177
DOI: 10.1074/jbc.M302344200

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