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Article

BRAF mutations in metastatic melanoma: a possible association with clinical outcome.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2003

Kumar Rajiv, Angelini Sabrina, Czene Kamila, Sauroja Ilari, Hahka-Kemppinen Marjo, Pyrhönen Seppo, Hemminki Kari

Abstract excerpt

PURPOSE: The RAS-RAF-mitogen-activated protein kinase pathways mediate the cellular response to growth signals. In melanocytes, BRAF is involved in cAMP-dependent growth signals. Recently, activating mutations in the BRAF gene, were reported in a large proportion of melanomas. We have studied mutations in the BRAF gene and their association with clinical parameters. EXPERIMENTAL DESIGN: We analyzed exons 1, 11,...

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Share to Genes, ras
Share to Melanoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multivariate Analysis

Share to Neoplasm Metastasis

Share to Polymorphism, Single-Stranded Conformational

Share to Proportional Hazards Models

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins c-raf

Source

Identifiers

PMID: 12960123

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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