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Article

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.

Cancer discovery - 1 Sept 2012

Dahlman Kimberly Brown, Xia Junfeng, Hutchinson Katherine, Ng Charles, Hucks Donald, Jia Peilin, Atefi Mohammad, Su Zengliu, Branch Suzanne, Lyle Pamela L, Hicks Donna J, Bozon Viviana, Glaspy John A, Rosen Neal, Solit David B, Netterville James L, Vnencak-Jones Cindy L, Sosman Jeffrey A, Ribas Antoni, Zhao Zhongming, Pao William

Abstract excerpt

UNLABELLED: Kinase inhibitors are accepted treatment for metastatic melanomas that harbor specific driver mutations in BRAF or KIT, but only 40% to 50% of cases are positive. To uncover other potential targetable mutations, we conducted whole-genome sequencing of a highly aggressive BRAF (V600) a...

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Source

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Identifiers

PMID: 22798288
DOI: 10.1158/2159-8290.CD-12-0097
PMCID: PMC3449158

Genes

BRAF
KIT
GNA11
GNAQ
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22798288-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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