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Article

Association study of Val66Met polymorphism in brain-derived neurotrophic factor gene with clozapine-induced metabolic syndrome: preliminary results.

PloS one - 1 Jan 2013

Zhang Yi, Chen Meijuan, Wu Zhiguo, Chen Jun, Yu Shunying, Fang Yiru, Zhang Chen

Abstract excerpt

The prevalence of the metabolic syndrome (MetS) is higher among patients receiving atypical antipsychotics (AAPs) treatment, and even among AAPs, treatment with clozapine has been shown to be associated with a higher long-term incidence rate of MetS. Likewise, brain-derived neurotrophic factor (BDNF) deficiency has been reported to result in metabolic traits, such as increased food intake, hyperphagia and...

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Identifiers

PMID: 23967328
DOI: 10.1371/journal.pone.0072652
PMCID: PMC3742721

Genes

BDNF

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