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Article

Inactivating mutations of caspase-8 gene in colorectal carcinomas.

Gastroenterology - 1 Sept 2003

Kim Hong Sug, Lee Jong Woo, Soung Young Hwa, Park Won Sang, Kim Su Young, Lee Jong Heun, Park Jik Young, Cho Youg Gu, Kim Chang Jae, Jeong Seong Whan, Nam Suk Woo, Kim Sang Ho, Lee Jung Young, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

BACKGROUND & AIMS: There has been evidence that dysregulation of apoptosis is involved in the pathogenesis of cancer development. Caspase-8 is an initiation caspase that activates the caspase cascade during apoptosis. The aim of this study was to explore the possibility that mutation of the caspase-8 gene might be involved in the development of colorectal cancer. METHODS: We analyzed the entire coding region of...

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Identifiers

PMID: 12949717
DOI: 10.1016/s0016-5085(03)01059-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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