Article
Mechanisms underlying DNA damage resistance in a Xiphophorus melanoma cell line.
Carcinogenesis - 1 Dec 2003
Moredock Steven, Nairn Rodney S, Johnston Dennis A, Byrom Michelle, Heaton Ginger, Lowery Megan, Mitchell David L
Abstract excerpt
The Xiphophorus hybrid fish model is an important resource for investigating the genetics and molecular biology of melanoma. Consistent with studies using human melanoma cell lines, the Xiphophorus melanoma cell line PSM, survives the lethal effects of ultraviolet-B radiation (UV-B) radiation much better than a cell line derived from normal fish tissue. In contrast to human melanoma cells, which show enhanced...
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