Hemochromatosis gene HFE Cys282Tyr mutation analysis in a cohort of Northeast German hospitalized patients supports assumption of a North to South allele frequency gradient throughout Germany.

Abstract excerpt

Hereditary hemochromatosis is the most common autosomal recessive disease in populations of Northern European ancestry. Population studies demonstrated highly variable frequencies of the HFE Cys282Tyr allele in various regions throughout Europe and decreasing allele frequencies from north to south. However, most of the German prevalence studies covered the central and southern regions of the country. The present...

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