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Article

Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung.

The Journal of biological chemistry - 21 Nov 2003

Wongtrakool Cherry, Malpel Sarah, Gorenstein Julie, Sedita Jeff, Ramirez Maria I, Underhill T Michael, Cardoso Wellington V

Abstract excerpt

Although retinoic acid (RA) has been shown to be critical for lung development, little is known about when RA is required and the role of individual RA receptors (RAR) in this process. Previously reported data from an RA responsive element RARE-lacZ reporter mouse show that when epithelial tubules are branching and differentiating RA signaling becomes markedly down-regulated in the epithelium. It is unclear why...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12947094
DOI: 10.1074/jbc.M307977200
PMCID: PMC2168590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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