Article
On the structural and functional importance of the highly conserved Glu56 of Thermus thermophilus L4 ribosomal protein.
Journal of molecular biology - 5 Sept 2003
Leontiadou Fotini, Xaplanteri Maria A, Papadopoulos Georgios, Gerassimou Christina, Kalpaxis Dimitrios L, Choli-Papadopoulou Theodora
Abstract excerpt
The structural and functional importance of the highly conserved amino acid residue glutamic acid 56 (Glu56) of the ribosomal protein L4 from Thermus thermophilus (TthL4) has been investigated by replacing this residue by alanine or glutamine, and by incorporating the resulted mutants into Escherichia coli ribosomes. The catalytic properties of peptidyltransferase estimated for the mutants as well as for the...
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