Article
Simultaneous polymerase chain reaction restriction fragment length polymorphism identification of the factor V Leiden allele and the prothrombin 20210A mutation.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 1998
Wisotzkey J D, Bell T, Monk J S
Abstract excerpt
A novel mutation in the 3' untranslated region of the prothrombin gene, prothrombin 20210A, recently has been identified. This mutation is associated with increased serum prothrombin levels and an increased risk for venous thromboembolism. Patients who carry a mutation in the factor V gene (facto...
Topics
- 3' Untranslated Regions
- Alleles
- DNA
- DNA Primers
- Factor V
- Heterozygote
- Humans
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Prothrombin
- Thromboembolism
- Venous Thrombosis