Article
Neuronal untranslated BC1 RNA: targeted gene elimination in mice.
Molecular and cellular biology - 1 Sept 2003
Skryabin Boris V, Sukonina Valentina, Jordan Ursula, Lewejohann Lars, Sachser Norbert, Muslimov Ilham, Tiedge Henri, Brosius Jürgen
Abstract excerpt
Despite the potentially important roles of untranslated RNAs in cellular form or function, genes encoding such RNAs have until now received surprisingly little attention. One such gene encodes BC1 RNA, a small non-mRNA that is delivered to dendritic microdomains in neurons. We have now eliminated the BC1 RNA gene in mice. Three independent founder lines were established from separate embryonic stem cells. The...
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