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Article

Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin.

Scientific reports - 7 Oct 2016

Huang Chu-Wei, Chen Yi-Wen, Lin Yi-Rou, Chen Po-Han, Chou Meng-Hsuan, Lee Li-Jen, Wang Pei-Yu, Wu June-Tai, Tsao Yeou-Ping, Chen Show-Li

Abstract excerpt

Breast carcinoma amplified sequence 2 (BCAS2) is a core component of the hPrP19 complex that controls RNA splicing. Here, we performed an exon array assay and showed that β-catenin is a target of BCAS2 splicing regulation. The regulation of dendrite growth and morphology by β-catenin is well documented. Therefore, we generated conditional knockout (cKO) mice to eliminate the BCAS2 expression in the forebrain to...

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Identifiers

PMID: 27713508
DOI: 10.1038/srep34927
PMCID: PMC5054673

Genes

BCAS2
DCX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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