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Article

Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase.

The Journal of biological chemistry - 3 Dec 2010

Bockelmann Svenja, Menche Dirk, Rudolph Sven, Bender Tobias, Grond Stephanie, von Zezschwitz Paultheo, Muench Stephen P, Wieczorek Helmut, Huss Markus

Abstract excerpt

The macrolactone archazolid is a novel, highly specific V-ATPase inhibitor with an IC(50) value in the low nanomolar range. The binding site of archazolid is presumed to overlap with the binding site of the established plecomacrolide V-ATPase inhibitors bafilomycin and concanamycin in subunit c of the membrane-integral V(O) complex. Using a semi-synthetic derivative of archazolid for photoaffinity labeling of the...

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Identifiers

PMID: 20884613
DOI: 10.1074/jbc.M110.137539
PMCID: PMC2992264

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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