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Article

Crystal structure and functional analysis of Drosophila Wind, a protein-disulfide isomerase-related protein.

The Journal of biological chemistry - 7 Nov 2003

Ma Qingjun, Guo Chaoshe, Barnewitz Kathrin, Sheldrick George M, Soling Hans-Dieter, Uson Isabel, Ferrari David M

Abstract excerpt

In the developing Drosophila melanogaster embryo, dorsal-ventral patterning displays an absolute requirement for the product of the essential windbeutel gene, Wind. In homozygous windbeutel mutant flies, dorsal-ventral patterning fails to initiate because of the failure of the Golgi-resident proteoglycan-modifying protein, Pipe, to exit the endoplasmic reticulum, and this leads to the death of the embryo. Here,...

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PMID: 12941941
DOI: 10.1074/jbc.M307966200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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