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Article

Level of an advanced glycated end product is genetically determined: a study of normal twins.

Diabetes - 1 Sept 2003

Leslie R David G, Beyan Huriya, Sawtell Pam, Boehm Bernard O, Spector Tim D, Snieder Harold

Abstract excerpt

Reducing sugars react with amino groups in proteins, lipids, and nucleic acids to produce advanced glycation end products (AGEs), including N(epsilon)-carboxymethyl lysine (CML), which have been implicated in oxidative stress and vascular damage. The aim of this study was to determine whether genetic factors influence serum CML levels in normal subjects. We performed a classical twin study of CML in healthy...

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Source

Identifiers

PMID: 12941787
DOI: 10.2337/diabetes.52.9.2441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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