Article
Free advanced glycation end product distribution in blood components and the effect of genetic polymorphisms.
Biochimie - 1 Dec 2020
Nomi Yuri, Kudo Hitomi, Miyamoto Kurenai, Okura Tsuyoshi, Yamamoto Kazuhiro, Shimohiro Hisashi, Kitao Sonoko, Ito Yuichi, Egawa Shigenobu, Kawahara Kazuo, Otsuka Yuzuru, Ueta Etsuko
Abstract excerpt
One hypothesis regarding the cause of diabetic complications is that advanced glycation end products (AGEs) bind to the AGE receptor and induce changes in gene expression. However, what AGEs exist in vivo and how individual AGEs are produced and impact body metabolic process to cause diabetes complications are not understood. We developed a new precise method to measure AGEs using LC-MS/MS with a new column and...
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