Article
The biological role of the carboxyl-terminal extension of human chorionic gonadotropin [corrected] beta-subunit.
Endocrinology - 1 Jan 1990
Matzuk M M, Hsueh A J, Lapolt P, Tsafriri A, Keene J L, Boime I
Abstract excerpt
hCG is a member of a family of glycoprotein hormones which share a common alpha-subunit, but differ in their hormone-specific beta-subunits. The CG beta-subunit is unique in that it contains a hydrophilic carboxyl-terminal extension with four serine O-linked oligosaccharides. To examine the role of the O-linked oligosaccharides and the carboxyl-terminal extension of hCG beta on receptor binding, steroidogenesis...
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