Article
N-glycosylation of the beta-propeller domain of the integrin alpha5 subunit is essential for alpha5beta1 heterodimerization, expression on the cell surface, and its biological function.
The Journal of biological chemistry - 3 Nov 2006
Isaji Tomoya, Sato Yuya, Zhao Yanyang, Miyoshi Eiji, Wada Yoshinao, Taniguchi Naoyuki, Gu Jianguo
Abstract excerpt
The N-glycosylation of integrin alpha5beta1 is thought to play crucial roles in cell spreading, cell migration, ligand binding, and dimer formation, but the underlying mechanism remains unclear. To investigate the importance of the N-glycans of this integrin in detail, sequential site-directed mu...
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