Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers.

European journal of clinical pharmacology - 1 Sept 2003

Otani Masahiro, Fukuda Tsuyoshi, Naohara Masakazu, Maune Hiromi, Senda Chiaki, Yamamoto Isamu, Azuma Junichi

Abstract excerpt

OBJECTIVE: In vitro studies with human liver microsomes have suggested that the oxidative conversion of mexiletine (MX) to its metabolites is catalyzed by CYP2D6 and is significantly impaired in microsomes with the CYP2D6*10/*10 genotype. Therefore, we examined the influence of the CYP2D6*10 alle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Anti-Arrhythmia Agents
Share to Area Under Curve

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, High Pressure Liquid

Share to Cytochrome P-450 CYP2D6

Share to Genotype

Share to Linear Models

Source

Identifiers

PMID: 12937870
DOI: 10.1007/s00228-003-0656-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12937870-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers.PMID 12937870Read ↗

Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes.Semantic proximity Read ↗

Two novel CYP2D6*10 haplotypes as possible causes of a poor metabolic phenotype in Japanese.Semantic proximity Read ↗

Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers.Semantic proximity Read ↗

Influence of the cytochrome P450 2D6 *10/*10 genotype on the pharmacokinetics of paroxetine in Japanese patients with major depressive disorder: a population pharmacokinetic analysis.Semantic proximity Read ↗

Pharmacokinetics, safety, and tolerability of atomoxetine and effect of CYP2D6*10/*10 genotype in healthy Japanese men.Semantic proximity Read ↗

Effect of CYP2D6*10 on pharmacokinetic variability of routinely administered metoprolol in middle-aged and elderly Japanese patients.Semantic proximity Read ↗

Effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects.Semantic proximity Read ↗

Effect of the CYP2D6*10 genotype on tolterodine pharmacokinetics.Semantic proximity Read ↗

Effects of CYP2D6 genetic polymorphism on the pharmacokinetics of metoclopramide.Semantic proximity Read ↗

The impact of CYP2D6 polymorphisms on the pharmacokinetics of codeine and its metabolites in Mongolian Chinese subjects.Semantic proximity Read ↗

Frequency of CYP2D6*10 and *14 alleles and their influence on the metabolic activity of CYP2D6 in a healthy Chinese population.Semantic proximity Read ↗

Cytochrome P450 2D6*10 genotype affects the pharmacokinetics of dimemorfan in healthy Chinese subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.