Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity.

doi:10.1128/JVI.79.21.13373-13384.2005

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Article

Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity.

Journal of virology - 1 Nov 2005

Li Jianrong, Fontaine-Rodriguez Errin C, Whelan Sean P J

Abstract excerpt

During mRNA synthesis, the polymerase of vesicular stomatitis virus (VSV) copies the genomic RNA to produce five capped and polyadenylated mRNAs with the 5'-terminal structure 7mGpppA(m)pApCpApGpNpNpApUpCp. The 5' mRNA processing events are poorly understood but presumably require triphosphatase, guanylyltransferase, [guanine-N-7]- and [ribose-2'-O]-methyltransferase (MTase) activities. Consistent with a role in...

Topics

Amino Acid Sequence
Animals
Catalytic Domain
Cell Line
Guanine
Molecular Sequence Data
Mutation
RNA Caps
RNA, Messenger
RNA, Viral
RNA-Dependent RNA Polymerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribose

Sequence Alignment

Vesicular stomatitis Indiana virus

Viral Proteins

Virus Replication

tRNA Methyltransferases

Source

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Identifiers

PMID: 16227259
DOI: 10.1128/JVI.79.21.13373-13384.2005
PMCID: PMC1262600

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Amino acid residues within conserved domain VI of the vesicular stomatitis virus large polymerase protein essential for mRNA cap methyltransferase activity.PMID 16227259Read ↗

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