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Article

Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis.

Journal of experimental & clinical cancer research : CR - 20 Apr 2017

Heublein Sabine, Mayr Doris, Meindl Alfons, Kircher Alexandra, Jeschke Udo, Ditsch Nina

Abstract excerpt

BACKGROUND: BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Due to these common targets being absent the application of anti-endocrine therapies is rather limited and a certain focus has been set on discovering alternative target molecules. We recently highlighted thyroid hormone receptors (TRs) to predict...

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Share to BRCA1 Protein
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PPAR gamma

Share to Receptors, Calcitriol

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Share to Triple Negative Breast Neoplasms

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Source

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Identifiers

PMID: 28427429
DOI: 10.1186/s13046-017-0517-1
PMCID: PMC5399435

Genes

BRCA1
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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