Article
Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments.
Endocrinology - 1 Sept 2003
Chiusaroli R, Maier A, Knight M C, Byrne M, Calvi L M, Baron R, Krane S M, Schipani E
Abstract excerpt
Expression of a constitutively active PTH/PTHrP receptor in cells of osteoblast lineage in vivo (CL2+) causes increases in trabecular bone volume and trabecular bone formation and, conversely, a decrease in the periosteal mineral apposition rate. Collagenase-3 (matrix metalloprotease-13) is a dow...
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