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Reduced Bone Mass in Collagen Prolyl 4‐Hydroxylase P4ha1 +/− ; P4ha2 −/− Compound Mutant Mice

14 Apr 2022

Abstract excerpt

ABSTRACT Proper deposition of the extracellular matrix and its major components, the collagens, is essential for endochondral ossification and bone mass accrual. Collagen prolyl 4‐hydroxylases (C‐P4Hs) hydroxylate proline residues in the ‐X‐Pro‐Gly‐ repeats of all known collagen types. Their product, 4‐hydroxyproline, is essential for correct folding and thermal stability of the triple‐helical collagen molecules...

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PMID: 35720665
DOI: 10.1002/jbm4.10630

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