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Article

Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time.

Nucleic acids research - 1 Sept 2003

Nakamura Jun, Asakura Shoji, Hester Susan D, de Murcia Gilbert, Caldecott Keith W, Swenberg James A

Abstract excerpt

DNA single strand breaks (SSBs) are one of the most frequent DNA lesions in genomic DNA generated either by oxidative stress or during the base excision repair pathways. Here we established a new real-time assay to assess an imbalance of DNA SSB repair by indirectly measuring PARP-1 activation th...

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Identifiers

PMID: 12930978
DOI: 10.1093/nar/gng105
PMCID: PMC212824

Genes

SSB
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12930978-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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