Article
Evaluation of a polymorphism in intron 2 of the p53 gene in ovarian cancer patients. From the Danish "Malova" Ovarian Cancer Study.
Anticancer research - 1 Jan 2000
Høgdall Estrid V, Kjaer Susanne K, Glud Eva, Christensen Lise, Blaakaer Jan, Vuust Jens, Bock Johannes E, Norgaard-Pedersen Bent, Hogdall Claus K
Abstract excerpt
BACKGROUND: The p53 gene is frequently mutated in various human tumours. In addition, single nucleotide polymorphisms are often observed in exons and introns of the p53 gene in normal tissues and tumours. MATERIALS AND METHODS: A total of 210 blood and tissue samples from 182 ovarian cancers (OC) and 28 ovarian borderline tumours, in addition to blood samples from 72 healthy women, were analysed. The used...
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