Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular characterization of peripherin-2 and rom-1 mutants responsible for digenic retinitis pigmentosa.

The Journal of biological chemistry - 22 Jun 2001

Loewen C J, Moritz O L, Molday R S

Abstract excerpt

Peripherin-2 and Rom-1 are homologous tetraspanning membrane proteins that assemble into noncovalent tetramers and higher order disulfide-linked oligomers implicated in photoreceptor disc morphogenesis. Individuals who coinherit a L185P peripherin-2 mutation and a null or G113E rom-1 mutation are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COS Cells
Share to Eye Proteins
Share to Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intermediate Filament Proteins

Share to Molecular Weight

Share to Peripherins

Share to Retinitis Pigmentosa

Share to Tetraspanins

Source

Identifiers

PMID: 11297544
DOI: 10.1074/jbc.M011710200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11297544-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular characterization of peripherin-2 and rom-1 mutants responsible for digenic retinitis pigmentosa.PMID 11297544Read ↗

Defective subunit assembly underlies a digenic form of retinitis pigmentosa linked to mutations in peripherin/rds and rom-1.Semantic proximity Read ↗

Expression and characterization of peripherin/rds-rom-1 complexes and mutants implicated in retinal degenerative diseases.Semantic proximity Read ↗

Role of the Second Intradiscal Loop of Peripherin/<i>rds </i>in Homo and Hetero AssociationsSemantic proximity Read ↗

The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis.Semantic proximity Read ↗

Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies.Semantic proximity Read ↗

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.Semantic proximity Read ↗

The role of subunit assembly in peripherin-2 targeting to rod photoreceptor disk membranes and retinitis pigmentosa.Semantic proximity Read ↗

Transgenic analysis of rds/peripherin N-glycosylation: effect on dimerization, interaction with rom1, and rescue of the rds null phenotype.Semantic proximity Read ↗

Peripherin/rds Influences Membrane Vesicle MorphologySemantic proximity Read ↗

Analysis of the rds/peripherin.rom1 complex in transgenic photoreceptors that express a chimeric protein.Semantic proximity Read ↗

Deficiency of rds/peripherin causes photoreceptor death in mouse models of digenic and dominant retinitis pigmentosa.Semantic proximity Read ↗

An intramembrane glutamic acid governs peripherin/rds function for photoreceptor disk morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.