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Article

Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma.

Molecular cancer therapeutics - 1 Apr 2015

Han Kyung Seok, Li Na, Raven Peter A, Fazli Ladan, Ettinger Susan, Hong Sung Joon, Gleave Martin E, So Alan I

Abstract excerpt

Renal cell carcinoma (RCC) is the most common malignancy in the kidney. Antiangiogenic targeted therapies inhibit the progression of RCC, but have limited impacts on invasion or metastasis of tumor cells. Integrin-linked kinase (ILK) is a serine/threonine kinase implicated in the regulation of cell growth/survival, cell-cycle progression, epithelial-mesenchymal transition (EMT), invasion/migration, and...

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Identifiers

PMID: 25657336
DOI: 10.1158/1535-7163.MCT-14-0771

Genes

ILK

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Targeting Integrin-Linked Kinase Suppresses Invasion and Metastasis through Downregulation of Epithelial-to-Mesenchymal Transition in Renal Cell Carcinoma.PMID 25657336Read ↗

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