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Article

Subtle cognitive impairment but no dementia in patients with spastin mutations.

Archives of neurology - 1 Aug 2003

Tallaksen Chantal M E, Guichart-Gomez Elodie, Verpillat Patrice, Hahn-Barma Valerie, Ruberg Merle, Fontaine Bertrand, Brice Alexis, Dubois Bruno, Durr Alexandra

Abstract excerpt

BACKGROUND: The most frequent form of autosomal dominant hereditary spastic paraparesis is associated with the SPG4 locus, described originally as a pure form of the disease. Mutations of the SPG4 gene have been increasingly associated with reports of cognitive impairment. OBJECTIVE: To investiga...

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Identifiers

PMID: 12925368
DOI: 10.1001/archneur.60.8.1113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12925368-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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