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Article

Cognitive profile in spastic paraplegia with thin corpus callosum and mutations in SPG11.

Neuropediatrics - 1 Feb 2010

Siri L, Battaglia F M, Tessa A, Rossi A, Rocco M Di, Facchinetti S, Mascaretti M, Santorelli F M, Veneselli E, Biancheri R

Abstract excerpt

Autosomal recessive hereditary spastic paraplegia with thinning of the anterior corpus callosum (ARHSP-TCC) due to mutations in SPG11 on chromosome 15q (MIM610844) is the single most common cause of ARHSP. It is characterized by slowly progressive paraparesis and peripheral neuropathy. Although cognitive impairment, sometimes diagnosed as mental retardation, is an almost invariable feature, the extent and...

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Source

Identifiers

PMID: 20571989
DOI: 10.1055/s-0030-1253352

Genes

SPG11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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