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Article

Age-related cognitive decline in hereditary spastic paraparesis linked to chromosome 2p.

Neurology - 11 Apr 2000

Byrne P C, Mc Monagle P, Webb S, Fitzgerald B, Parfrey N A, Hutchinson M

Abstract excerpt

OBJECTIVES: To investigate whether cognitive decline is part of the phenotype of SPG4-linked hereditary spastic paraparesis (HSP) and to determine whether cognitive changes are present in haplotype carriers before the onset of paraparesis. BACKGROUND: The major locus for "pure" autosomal dominant HSP is the SPG4 locus on chromosome 2p. Cognitive impairment linked to this locus has been described in two families....

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Identifiers

PMID: 10751268
DOI: 10.1212/wnl.54.7.1510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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