Further evidence of dementia in <i>SPG4</i> -linked autosomal dominant hereditary spastic paraplegia

Abstract excerpt

OBJECTIVE: To investigate the progression of cognitive impairment and its behavioral aspects in patients with SPG4-linked autosomal dominant hereditary spastic paraplegia (SPG4-ADHSP). METHODS: Sixteen patients, 45 years or older, from five families with SPG4-ADHSP were prospectively assessed. Eleven of these, from three families, were followed and 10 had two cognitive examinations using the Cambridge Cognitive...

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