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Article

Overlapping neuropathological findings in an asymptomatic SPAST gene mutation carrier.

Clinical neuropathology - 1 Jan 2000

Forcén Sara, Crespo Cuevas Ane Miren, Aldecoa Iban, Ramos Oscar, Ispierto Lourdes, Álvarez Ramiro, Vilas Dolores

Abstract excerpt

Hereditary spastic paraparesis (HSP) caused by mutations in the SPAST (SPG4) gene are autosomal-dominant inherited disorders characterized by weakness of lower extremities, spasticity and hyperreflexia. Some cases with cognitive decline have been repored. Herein we present an asymptomatic carrier of a SPAST gene mutation who developed an adult-onset cognitive decline, compatible with Alzheimer's disease with...

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Identifiers

PMID: 32213280
DOI: 10.5414/NP301239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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