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Article

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2003

Kim Hye-Sun, Kim Eun-Mee, Lee Jean-Pyo, Park Cheol Hyoung, Kim Seonghan, Seo Ji-Heui, Chang Keun-A, Yu Eunah, Jeong Sung-Jin, Chong Young Hae, Suh Yoo-Hun

Abstract excerpt

The AICD (amyloid precursor protein [APP] intracellular domain) and C31, the caspase-cleaved C-terminal fragment of APP, have been found in the brains of patients with Alzheimer's disease (AD). Here, we demonstrate for the first time that the C-terminal fragments of APP (AICD [C57, C59] and C31) exert neurotoxicity on differentiated PC 12 cells and rat primary cortical neurons by inducing the expression of...

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Source

Identifiers

PMID: 12923068
DOI: 10.1096/fj.03-0106fje

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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