Article
Chondroitin sulfate proteoglycans are required for lung growth and morphogenesis in vitro.
American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2003
Shannon John M, McCormick-Shannon Kathleen, Burhans Michael S, Shangguan Xiaofei, Srivastava Kalpana, Hyatt Brian A
Abstract excerpt
Proteoglycans (PGs) have been shown to play a key role in the development of many tissues. We have investigated the role of sulfated PGs in early rat lung development by treating cultured tissues with 30 mM sodium chlorate, a global inhibitor of PG sulfation. Chlorate treatment disrupted growth and branching of embryonic day 13 lung explants. Isolated lung epithelium (LgE) migrated toward and invaded lung...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.