Article
[Phylogenetic analysis and pathogenicity of tick-borne encephalitis virus from Japan and far-east Russia].
Uirusu - 1 Jun 2005
Takashima Ikuo, Hayasaka Daisuke, Goto Akiko, Yoshii Kentarou, Kariwa Hiroaki
Abstract excerpt
Phylogenetic analysis of tick-borne encephalitis (TBE) virus revealed that Hokkaido strain of TBE virus evolved several hundreds years ago in far-east Russia. TBE virus strains in Irkutsk area were identified as Siberian subtype of TBE virus. BHK-cell adapted mutant of TBE virus showed lower neuro-invasive virulence in mice than parent virus. The mutant carried one amino acid substitution in envelope protein...
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