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Article

Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans.

Pharmacotherapy - 1 Aug 2003

Parker Robert B, Yates C Ryan, Soberman Judith E, Laizure S Casey

Abstract excerpt

STUDY OBJECTIVES: To determine the effects of grapefruit juice on the pharmacokinetics of oral digoxin, a P-glycoprotein substrate not metabolized by cytochrome P450 3A4, in healthy volunteers, and to assess whether polymorphic multidrug-resistance-1 (MDR1) expression contributes to interindividual variability in digoxin disposition. DESIGN: Prospective, open-label, unblinded, crossover study. SETTING: University...

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Source

Identifiers

PMID: 12921244
DOI: 10.1592/phco.23.8.979.32881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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