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Article

Grapefruit juice inhibits the metabolic activation of clopidogrel.

Clinical pharmacology and therapeutics - 1 Mar 2014

Holmberg M T, Tornio A, Neuvonen M, Neuvonen P J, Backman J T, Niemi M

Abstract excerpt

Cytochrome P450 (CYP) enzymes, including CYP2C19 and CYP3A4, participate in the bioactivation of clopidogrel. Grapefruit juice constituents potently inactivate intestinal CYP3A4 and have been shown to inhibit CYP2C19 as well. In a randomized crossover study, 14 healthy volunteers ingested 200 ml...

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PMID: 24067745
DOI: 10.1038/clpt.2013.192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24067745-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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