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Article

The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide.

British journal of clinical pharmacology - 1 Jan 2006

Bidstrup Tanja Busk, Damkier Per, Olsen Anette Kristensen, Ekblom Marianne, Karlsson Anders, Brøsen Kim

Abstract excerpt

AIMS: The primary aim of the study was to investigate the possible effect of the CYP2C8*3 allele and of grapefruit juice on the pharmacokinetics of repaglinide. Furthermore, the impact of a single dose of grapefruit juice on the pharmacokinetics of repaglinide in relation to dose. METHODS: Thirty-six healthy male subjects, genotyped for CYP2C8*3 (11 genotyped as CYP2C8*1/*3, one as CYP2C8*3/*3 and 24 as...

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Identifiers

PMID: 16390351
DOI: 10.1111/j.1365-2125.2005.02516.x
PMCID: PMC1884987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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