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Article

Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

International journal of cancer - 10 Oct 2003

Pecere Teresa, Sarinella Federica, Salata Cristiano, Gatto Barbara, Bet Alessandra, Dalla Vecchia Francesca, Diaspro Alberto, Carli Modesto, Palumbo Manlio, Palù Giorgio

Abstract excerpt

Previously, we have identified aloe-emodin (AE) as a new type of anticancer agent, with activity that is based on apoptotic cell death promoted by a neuroectodermal tumor-specific drug uptake. We attempt to clarify the intracellular target of AE and the apoptosis-signaling pathway activated by AE...

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Identifiers

PMID: 12918060
DOI: 10.1002/ijc.11312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12918060-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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