Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of p53 explains isotretinoin's teratogenicity

20 Aug 2017

Abstract excerpt

The precise molecular basis of retinoid embryopathy is yet unknown. This hypothesis predicts that isotretinoin (13-cis retinoic acid), the prodrug of all-trans retinoic acid (ATRA), exaggerates neural crest cell (NCC) apoptosis via upregulation of the pro-apoptotic transcription factor p53, the guardian of the genome. Increased p53 signalling is associated with Treacher Collins-, CHARGE- and fetal alcohol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Ear and Nasal Anomalies
Share to Hedgehog Signaling Pathway Studies
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28833556
DOI: 10.1111/exd.13420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of p53 explains isotretinoin's teratogenicityPMID 28833556Read ↗

Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgarisSemantic proximity Read ↗

Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects.Semantic proximity Read ↗

Expression and Role of p53 in the RetinaSemantic proximity Read ↗

Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation functionSemantic proximity Read ↗

p53 upregulation is a frequent response to deficiency of cell-essential genes.Semantic proximity Read ↗

The p53 family in nervous system development and diseaseSemantic proximity Read ↗

Loss of Nance-Horan Syndrome b ( <i>nhsb</i> ) prevents expansion growth of retinal progenitor cells by selective up-regulation of <i>Δ113p53</i>Semantic proximity Read ↗

Loss of tumor protein 53 protects against alcohol‐induced facial malformations in mice and zebrafishSemantic proximity Read ↗

Differences in neural crest sensitivity to ethanol account for the infrequency of anterior segment defects in the eye compared with craniofacial anomalies in a zebrafish model of fetal alcohol syndromeSemantic proximity Read ↗

Restoration of polr1c in Early Embryogenesis Rescues the Type 3 Treacher Collins Syndrome Facial Malformation Phenotype in Zebrafish.Semantic proximity Read ↗

What's retinoic acid got to do with it? Retinoic acid regulation of the neural crest in craniofacial and ocular developmentSemantic proximity Read ↗

Teratogenic effect of isotretinoin in both fertile females and males (Review)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.