Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutator phenotype of MUTYH-null mouse embryonic stem cells.

The Journal of biological chemistry - 3 Oct 2003

Hirano Seiki, Tominaga Yohei, Ichinoe Akimasa, Ushijima Yasuhiro, Tsuchimoto Daisuke, Honda-Ohnishi Yoko, Ohtsubo Toshio, Sakumi Kunihiko, Nakabeppu Yusaku

Abstract excerpt

To evaluate the antimutagenic role of a mammalian mutY homolog, namely the Mutyh gene, which encodes adenine DNA glycosylase excising adenine misincorporated opposite 8-oxoguanine in the template DNA, we generated MUTYH-null mouse embryonic stem (ES) cells. In the MUTYH-null cells carrying no ade...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to DNA Glycosylases
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Genetic Vectors

Share to N-Glycosyl Hydrolases

Share to Proliferating Cell Nuclear Antigen

Share to Stem Cells

Source

Identifiers

PMID: 12917422
DOI: 10.1074/jbc.C300316200

Genes

MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12917422-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutator phenotype of MUTYH-null mouse embryonic stem cells.PMID 12917422Read ↗

Functional interaction of MutY homolog with proliferating cell nuclear antigen in fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis.Semantic proximity Read ↗

MutY and MutY homologs (MYH) in genome maintenance.Semantic proximity Read ↗

Heterozygous deleterious MUTYH variants as a driver for tumorigenesisSemantic proximity Read ↗

MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.Semantic proximity Read ↗

Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.Semantic proximity Read ↗

Reduced expression of MUTYH with suppressive activity against mutations caused by 8-hydroxyguanine is a novel predictor of a poor prognosis in human gastric cancer.Semantic proximity Read ↗

Functional characterization of two human MutY homolog (hMYH) missense mutations (R227W and V232F) that lie within the putative hMSH6 binding domain and are associated with hMYH polyposisSemantic proximity Read ↗

Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase.Semantic proximity Read ↗

Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair.Semantic proximity Read ↗

Fission yeast (Schizosaccharomyces pombe) cells defective in the MutY-homologous glycosylase activity have a mutator phenotype and are sensitive to hydrogen peroxide.Semantic proximity Read ↗

MUTYH mutations associated with familial adenomatous polyposis: functional characterization by a mammalian cell-based assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.