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Article

Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity.

Journal of virology - 1 Dec 2004

Harcourt Brian H, Jukneliene Dalia, Kanjanahaluethai Amornrat, Bechill John, Severson Kari M, Smith Catherine M, Rota Paul A, Baker Susan C

Abstract excerpt

Gene 1 of the coronavirus associated with severe acute respiratory syndrome (SARS) encodes replicase polyproteins that are predicted to be processed into 16 nonstructural proteins (nsps 1 to 16) by two viral proteases, a papain-like protease (PLpro) and a 3C-like protease (3CLpro). Here, we identify SARS coronavirus amino-terminal replicase products nsp1, nsp2, and nsp3 and describe trans-cleavage assays that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15564471
DOI: 10.1128/JVI.78.24.13600-13612.2004
PMCID: PMC533933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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