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Article

The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Aug 2003

Einat Haim, Yuan Peixiong, Gould Todd D, Li Jianling, Du JianHua, Zhang Lei, Manji Husseini K, Chen Guang

Abstract excerpt

The neurobiological underpinnings of mood modulation, molecular pathophysiology of manic-depressive illness, and therapeutic mechanism of mood stabilizers are largely unknown. The extracellular signal-regulated kinase (ERK) pathway is activated by neurotrophins and other neuroactive chemicals to...

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Identifiers

PMID: 12917364
PMCID: PMC6740453

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12917364-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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