Article
Association of TNF-alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population.
Journal of viral hepatitis - 1 Sept 2006
Du T, Guo X-H, Zhu X-L, Li J-H, Lu L-P, Gao J-R, Gou C-Y, Li Z, Liu Y, Li H
Abstract excerpt
Host genetic factors and environment factors including hepatitis B virus (HBV) genotypes are widely studied for the different outcomes of HBV infection. Recent studies suggest that tumour necrosis factor-alpha (TNF-alpha) plays a pivotal role in the viral clearance and host immune response to HBV, and the capacity for TNF-alpha production in individuals is influenced by a major genetic component. In this study,...
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