Article
Catalytically active human telomerase mutants with allele-specific biological properties.
Experimental cell research - 15 Aug 2003
Kim Moses, Xu Lifeng, Blackburn Elizabeth H
Abstract excerpt
Expression of the catalytic subunit of human telomerase, hTERT, extends human primary fibroblast life span. Such life span extension has generally been reported to be accompanied by net telomere lengthening, which led to the hypothesis that it is the telomere lengthening that causes the life span extension. Here we show that hTERT+C and hTERT-FlagC, mutant telomerase proteins with either 10 additional residues or...
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