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Article

A Fanca knockout mouse model reveals novel Fancd2 function.

Biochemical and biophysical research communications - 12 Feb 2024

Wang Qian, Liu Jia, Zhong Yixinhe, Li Dongbo, Zhong Yusen, Ying Huazhong, Zhang Tingting

Abstract excerpt

Fanconi anemia (FA) is a genetically and clinically heterogenous inherited disorder. Clinically, Fanca subtype patients exhibited milder phenotypes compared to Fancd2 subtypes. Increasing evidence suggests that Fancd2 perform independent functions, but the detailed mechanisms are not well characterized. In this study, we developed a Fanca KO mice model in C57BL/6 background with ATG region deletion, then...

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Identifiers

PMID: 38217981
DOI: 10.1016/j.bbrc.2023.149454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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