Article
Cidea-deficient mice have lean phenotype and are resistant to obesity.
Nature genetics - 1 Sept 2003
Zhou Zhihong, Yon Toh Shen, Chen Zhengming, Guo Ke, Ng Chee Peng, Ponniah Sathivel, Lin Sheng-Cai, Hong Wanjin, Li Peng
Abstract excerpt
The thermogenic activity of brown adipose tissue (BAT), important for adaptive thermogenesis and energy expenditure, is mediated by the mitochondrial uncoupling protein1 (Ucp1) that uncouples ATP generation and dissipates the energy as heat. We show here that Cidea, a protein of unknown function sharing sequence similarity with the N-terminal region of DNA fragmentation factors Dffb and Dffa, is expressed at high...
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