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[Structural mechanism studies of hTNF alpha mutants in position 30 and 42 amino acid].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Apr 2002

Hu Fang, Dong Shao-zhong, Liu Long-ding, He Shao-qing, Zhao Shu-dong, Li Qi-han

Abstract excerpt

OBJECTIVE: To study the relationship between the structure and functional activity of hTNF alpha. METHODS: Four hTNF alpha mutants were constructed, different binding structures and gene responses related with these mutants were studied by the methods of immunoprecipitation and mRNA differential display. RESULTS: The specific activities and LD50 of the different hTNF alpha mutants indicated their different...

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PMID: 12905791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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