Article
[Computer modeling and experimental research of interactions between two anti-hTNF alpha monoclonal antibody variable regions and hTNF alpha].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Jan 2000
Chen J J, Sun M, Fang J, Liu H, Chen C Q, Wang D B
Abstract excerpt
On SGI workstation, we constructed two anti-hTNF alpha McAbs by means of homologous protein-structure-prediction method. And then, on the basis of relative experimental results and the surface properties of hTNF alpha and two McAbs, we performed the docking of hTNF alpha into two anti-hTNF alpha McAbs. In order to confirm the models, we prepared two hTNF alpha mutants designed according to the binding models,...
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